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rdf:type |
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lifeskim:mentions |
umls-concept:C0004368,
umls-concept:C0011854,
umls-concept:C0018213,
umls-concept:C0024264,
umls-concept:C0332120,
umls-concept:C0439097,
umls-concept:C0521425,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1705241,
umls-concept:C1823153,
umls-concept:C2349976
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pubmed:issue |
2
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pubmed:dateCreated |
1993-6-8
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pubmed:abstractText |
Endocrine autoimmune disorders are mediated by T cell-dependent responses to organ-specific antigens, but the mechanisms initiating the process remain unknown. Lymphocytes which use the gamma delta heterodimer as T cell receptor (TCR) for antigen constitute a distinct subset of T cells whose function remains elusive. In order to investigate their possible involvement in endocrine autoimmunity we have determined the proportion of gamma delta T cells in the peripheral blood of 23 patients with type 1 (insulin-dependent) diabetes mellitus (type-1 DM) and 30 patients with autoimmune thyrotoxicosis (Graves' disease). T lymphocyte TCR expression was assessed by fluorescence-activated flow cytometry on peripheral blood mononuclear cells using MoAbs UCHT1 (CD3), TCR delta 1 (gamma delta TCR), WT31 and beta F1 (alpha beta TCR) and both the percentage of T cells expressing gamma delta and the ratio gamma delta/alpha beta were calculated. In the diabetic patients gamma delta cells were not significantly different from the control group (7.7 +/- 54% versus 8.0 +/- 5.5% of T cells, P NS). There was no relation between the proportion of gamma delta lymphocytes and the presence of islet cell antibodies (ICA) in the sera. The Graves' patients showed a tendency towards a higher proportion of gamma delta T lymphocytes than the controls (gamma delta/alpha beta ratios: 0.095 +/- 0.047 versus 0.063 +/- 0.022, P = 0.03). In 14 Graves' patients the number of gamma delta were measured in paired samples of peripheral and intrathyroidal lymphocytes, demonstrating an expansion of gamma delta within the thyroid glands (0.21 +/- 0.3 versus 0.095 +/- 0.047, P = 0.032). Immunohistochemical studies showed that gamma delta cells were scattered among the predominant alpha beta lymphocytes infiltrating the thyroid gland and that they account for 10% of intraepithelial lymphocytes. No relation was found between the increase of gamma delta lymphocytes and any clinical features.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-1348415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-1373059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-1378365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-1650757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-1671565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-1677929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-1708262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-1839880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-1899065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-1986381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2329261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2370425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2458531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2461518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2469770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2481336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2524098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2528206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2564416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2572671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2671237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-2978114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-3276724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-3672118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-3930110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-4139522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8485915-6138646
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
288-95
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8485915-Adolescent,
pubmed-meshheading:8485915-Adult,
pubmed-meshheading:8485915-Age Factors,
pubmed-meshheading:8485915-Autoimmune Diseases,
pubmed-meshheading:8485915-Child,
pubmed-meshheading:8485915-Diabetes Mellitus, Type 1,
pubmed-meshheading:8485915-Female,
pubmed-meshheading:8485915-Fluorescent Antibody Technique,
pubmed-meshheading:8485915-Graves Disease,
pubmed-meshheading:8485915-Humans,
pubmed-meshheading:8485915-Immunophenotyping,
pubmed-meshheading:8485915-Male,
pubmed-meshheading:8485915-Middle Aged,
pubmed-meshheading:8485915-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:8485915-T-Lymphocyte Subsets,
pubmed-meshheading:8485915-Thyroid Gland
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pubmed:year |
1993
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pubmed:articleTitle |
Gamma delta lymphocytes in endocrine autoimmunity: evidence of expansion in Graves' disease but not in type 1 diabetes.
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pubmed:affiliation |
Immunology Unit, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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