Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-6-10
pubmed:abstractText
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) has been recently reported as a cause of stroke. It is characterized, in the absence of hypertension, by recurrent subcortical ischaemic strokes, starting in early or midadulthood and leading in some patients to dementia. Magnetic resonance imaging and pathological examination show numerous small subcortical infarcts and a diffuse leukoencephalopathy underlaid by a non-arteriosclerotic, non-amyloid angiopathy. We performed genetic linkage analysis in two unrelated families and assigned the disease locus to chromosome 19q12. Multilocus analysis with the location scores method established the best estimate for the location of the affected gene within a 14 centimorgan interval bracketed by D19S221 and D19S222 loci.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1061-4036
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
256-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:8485581-Adult, pubmed-meshheading:8485581-Brain, pubmed-meshheading:8485581-Cerebral Arterial Diseases, pubmed-meshheading:8485581-Cerebral Arteries, pubmed-meshheading:8485581-Cerebral Infarction, pubmed-meshheading:8485581-Chromosome Mapping, pubmed-meshheading:8485581-Chromosomes, Human, Pair 19, pubmed-meshheading:8485581-Female, pubmed-meshheading:8485581-Genes, Dominant, pubmed-meshheading:8485581-Genetic Linkage, pubmed-meshheading:8485581-Genetic Markers, pubmed-meshheading:8485581-Humans, pubmed-meshheading:8485581-Leukoencephalopathy, Progressive Multifocal, pubmed-meshheading:8485581-Magnetic Resonance Imaging, pubmed-meshheading:8485581-Male, pubmed-meshheading:8485581-Middle Aged, pubmed-meshheading:8485581-Pedigree, pubmed-meshheading:8485581-Polymerase Chain Reaction, pubmed-meshheading:8485581-Syndrome
pubmed:year
1993
pubmed:articleTitle
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy maps to chromosome 19q12.
pubmed:affiliation
Laboratoire de Pathologie de l'Immunité (INSERM CJF 90-01), Faculté de Médecine Necker-Enfants Malades, Paris, France.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't