| pubmed-article:8485304 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8485304 | lifeskim:mentions | umls-concept:C0021831 | lld:lifeskim |
| pubmed-article:8485304 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:8485304 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8485304 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8485304 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8485304 | pubmed:dateCreated | 1993-6-10 | lld:pubmed |
| pubmed-article:8485304 | pubmed:abstractText | Tumour necrosis factor (TNF)-alpha has been implicated in the pathogenesis of experimental and clinical enteropathy, but its exact role is unknown. We show here that a single dose of TNF-alpha causes significant small intestinal pathology in normal adult mice, which develops within 15 minutes, persists for up to 48 hours and is enhanced by interferon-gamma (IFN-gamma). The enteropathy consists of villus atrophy and crypt hyperplasia and is therefore similar to that found in immunologically mediated enteropathies such as graft-versus-host reaction (GvHR). TNF-alpha is also cytotoxic to an intestinal crypt cell line in vitro. Thus, a direct action of TNF-alpha on crypt cells may be involved in its enteropathic effects in vivo. Together, these findings indicate that TNF-alpha alone, or in concert with other cytokines, may be an important effector molecule in immunologically mediated intestinal pathology and may ultimately provide a target for specific immunotherapy for clinical enteropathies. | lld:pubmed |
| pubmed-article:8485304 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8485304 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8485304 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8485304 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8485304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8485304 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8485304 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8485304 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8485304 | pubmed:issn | 1043-4666 | lld:pubmed |
| pubmed-article:8485304 | pubmed:author | pubmed-author:NicholsB LBL | lld:pubmed |
| pubmed-article:8485304 | pubmed:author | pubmed-author:MowatA MAM | lld:pubmed |
| pubmed-article:8485304 | pubmed:author | pubmed-author:BunceCC | lld:pubmed |
| pubmed-article:8485304 | pubmed:author | pubmed-author:GarsidePP | lld:pubmed |
| pubmed-article:8485304 | pubmed:author | pubmed-author:TomlinsonR... | lld:pubmed |
| pubmed-article:8485304 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8485304 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:8485304 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8485304 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8485304 | pubmed:pagination | 24-30 | lld:pubmed |
| pubmed-article:8485304 | pubmed:dateRevised | 2009-9-29 | lld:pubmed |
| pubmed-article:8485304 | pubmed:meshHeading | pubmed-meshheading:8485304-... | lld:pubmed |
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| pubmed-article:8485304 | pubmed:meshHeading | pubmed-meshheading:8485304-... | lld:pubmed |
| pubmed-article:8485304 | pubmed:meshHeading | pubmed-meshheading:8485304-... | lld:pubmed |
| pubmed-article:8485304 | pubmed:meshHeading | pubmed-meshheading:8485304-... | lld:pubmed |
| pubmed-article:8485304 | pubmed:meshHeading | pubmed-meshheading:8485304-... | lld:pubmed |
| pubmed-article:8485304 | pubmed:meshHeading | pubmed-meshheading:8485304-... | lld:pubmed |
| pubmed-article:8485304 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8485304 | pubmed:articleTitle | Analysis of enteropathy induced by tumour necrosis factor alpha. | lld:pubmed |
| pubmed-article:8485304 | pubmed:affiliation | Department of Immunology, University of Glasgow, Western Infirmary. | lld:pubmed |
| pubmed-article:8485304 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8485304 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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