Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1993-6-9
|
pubmed:abstractText |
In a placebo-controlled study, 43 patients with stable ulcerative colitis were randomized to receive either MaxEPA (n = 16), super evening primrose oil (n = 19), or olive oil as placebo (n = 8) for 6 months, in addition to their usual treatment. Treatment with MaxEPA increased red-cell membrane concentrations of eicosapentaenoic acid (EPA) at 3 months by three-fold and at 6 months by four-fold (both P < 0.01), and doubled docosahexaenoic acid (DHA) levels at 6 months (P < 0.05). Treatment with super evening primrose oil increased red-cell membrane concentrations of dihomogamma-linolenic acid (DGLA) by 40% at 6 months (P < 0.05), whilst treatment with placebo reduced levels of DGLA and DHA at 6 months (both P < 0.05). Clinical outcome was assessed by patient diary cards, sigmoidoscopy and histology of rectal biopsy specimens. Super evening primrose oil significantly improved stool consistency compared to MaxEPA and placebo at 6 months, and this difference was maintained 3 months after treatment was discontinued (P < 0.05). There was however, no difference in stool frequency, rectal bleeding, disease relapse, sigmoidoscopic appearance or rectal histology in the three treatment groups. Despite manipulation of cell-membrane fatty acids, fish oils do not exert a therapeutic effect in ulcerative colitis, while evening primrose oil may be of some benefit.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Docosahexaenoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Eicosapentaenoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Omega-3,
http://linkedlifedata.com/resource/pubmed/chemical/Fish Oils,
http://linkedlifedata.com/resource/pubmed/chemical/Maxepa,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Oils
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0269-2813
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
7
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
159-66
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:8485269-Aged,
pubmed-meshheading:8485269-Colitis, Ulcerative,
pubmed-meshheading:8485269-Docosahexaenoic Acids,
pubmed-meshheading:8485269-Drug Combinations,
pubmed-meshheading:8485269-Eicosapentaenoic Acid,
pubmed-meshheading:8485269-Erythrocyte Membrane,
pubmed-meshheading:8485269-Fatty Acids,
pubmed-meshheading:8485269-Fatty Acids, Omega-3,
pubmed-meshheading:8485269-Female,
pubmed-meshheading:8485269-Fish Oils,
pubmed-meshheading:8485269-Humans,
pubmed-meshheading:8485269-Male,
pubmed-meshheading:8485269-Middle Aged,
pubmed-meshheading:8485269-Plant Oils
|
pubmed:year |
1993
|
pubmed:articleTitle |
A randomized controlled study of evening primrose oil and fish oil in ulcerative colitis.
|
pubmed:affiliation |
Gastrointestinal Laboratory, Rayne Institute, St Thomas' Hospital, London, UK.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|