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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5109
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pubmed:dateCreated |
1993-6-1
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pubmed:abstractText |
The hematopoietically expressed product of the vav proto-oncogene, Vav, shared homology with guanine nucleotide releasing factors (GRFs) [also called guanosine diphosphate-dissociation stimulators (GDSs)] that activate Ras-related small guanosine triphosphate (GTP)-binding proteins. Human T cell lysates or Vav immunoprecipitates possessed GRF activity that increased after T cell antigen receptor (TCR)-CD3 triggering; an in vitro-translated Vav fragment that contained the putative GRF domain was also active. Vav-associated GRF stimulation after TCR-CD3 ligation paralleled its tyrosine phosphorylation; both were blocked by a protein tyrosine kinase (PTK) inhibitor. Vav also was a substrate for the p56lck PTK. Thus, Vav is a PTK-regulated GRF that may be important in TCR-CD3-initiated signal transduction through the activation of Ras.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Lactams, Macrocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Specific Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Muromonab-CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-vav,
http://linkedlifedata.com/resource/pubmed/chemical/Quinones,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor-CD3 Complex, Antigen...,
http://linkedlifedata.com/resource/pubmed/chemical/VAV1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/herbimycin,
http://linkedlifedata.com/resource/pubmed/chemical/rap GTP-Binding Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
260
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
822-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8484124-Benzoquinones,
pubmed-meshheading:8484124-Cell Cycle Proteins,
pubmed-meshheading:8484124-Fungal Proteins,
pubmed-meshheading:8484124-GTP-Binding Proteins,
pubmed-meshheading:8484124-Guanosine Diphosphate,
pubmed-meshheading:8484124-Guanosine Triphosphate,
pubmed-meshheading:8484124-Humans,
pubmed-meshheading:8484124-Lactams, Macrocyclic,
pubmed-meshheading:8484124-Lymphocyte Activation,
pubmed-meshheading:8484124-Lymphocyte Specific Protein Tyrosine Kinase p56(lck),
pubmed-meshheading:8484124-Muromonab-CD3,
pubmed-meshheading:8484124-Phosphorylation,
pubmed-meshheading:8484124-Protein-Tyrosine Kinases,
pubmed-meshheading:8484124-Proto-Oncogene Proteins,
pubmed-meshheading:8484124-Proto-Oncogene Proteins c-vav,
pubmed-meshheading:8484124-Quinones,
pubmed-meshheading:8484124-Receptor-CD3 Complex, Antigen, T-Cell,
pubmed-meshheading:8484124-Signal Transduction,
pubmed-meshheading:8484124-T-Lymphocytes,
pubmed-meshheading:8484124-Tumor Cells, Cultured,
pubmed-meshheading:8484124-rap GTP-Binding Proteins
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pubmed:year |
1993
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pubmed:articleTitle |
Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation.
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pubmed:affiliation |
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA 92037.
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pubmed:publicationType |
Journal Article,
Comment,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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