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pubmed-article:8483917pubmed:abstractTextTo augment the chemical potential of the immunological repertoire, a metal ion-binding light chain has been introduced into the murine genome. Mice containing the transgene were subsequently immunized with a fluorescein conjugate. The transgenic light chain was found at a high frequency in the anti-fluorescein memory B-cell compartment. This general method should be applicable to other cofactors and small molecules and should lead to generation of antibodies with unique catalytic activities.lld:pubmed
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pubmed-article:8483917pubmed:articleTitleIncreasing the chemical potential of the germ-line antibody repertoire.lld:pubmed
pubmed-article:8483917pubmed:affiliationDepartment of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.lld:pubmed
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pubmed-article:8483917pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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