|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1993-6-1
|
|
pubmed:abstractText |
To augment the chemical potential of the immunological repertoire, a metal ion-binding light chain has been introduced into the murine genome. Mice containing the transgene were subsequently immunized with a fluorescein conjugate. The transgenic light chain was found at a high frequency in the anti-fluorescein memory B-cell compartment. This general method should be applicable to other cofactors and small molecules and should lead to generation of antibodies with unique catalytic activities.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-1372394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-1584777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-1713127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-1730928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-1744576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-1898987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-1909739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-1924327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-1944535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-2024118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-2116666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-2413119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-2649247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-3104790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-3140379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-3262202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-6417544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8483917-6438533
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
90
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4008-11
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:8483917-Animals,
pubmed-meshheading:8483917-Antibody Formation,
pubmed-meshheading:8483917-B-Lymphocytes,
pubmed-meshheading:8483917-Base Sequence,
pubmed-meshheading:8483917-Crosses, Genetic,
pubmed-meshheading:8483917-Exons,
pubmed-meshheading:8483917-Hybridomas,
pubmed-meshheading:8483917-Immunoglobulin kappa-Chains,
pubmed-meshheading:8483917-Liver,
pubmed-meshheading:8483917-Mice,
pubmed-meshheading:8483917-Mice, Inbred Strains,
pubmed-meshheading:8483917-Mice, Transgenic,
pubmed-meshheading:8483917-Molecular Sequence Data,
pubmed-meshheading:8483917-Mutagenesis, Site-Directed,
pubmed-meshheading:8483917-Oligodeoxyribonucleotides,
pubmed-meshheading:8483917-Polymerase Chain Reaction,
pubmed-meshheading:8483917-Restriction Mapping,
pubmed-meshheading:8483917-Spleen,
pubmed-meshheading:8483917-Tumor Cells, Cultured
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Increasing the chemical potential of the germ-line antibody repertoire.
|
|
pubmed:affiliation |
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
