Linked Life Data

8483799

Source:http://linkedlifedata.com/resource/pubmed/id/8483799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-5-28
pubmed:abstractText
An in vitro model was developed to study the regulation of motilin release from its endocrine-producing cell. Enzymatically dispersed cells from canine duodenojejunal mucosa were separated by centrifugal counterflow elutriation to enrich motilin content. From the motilin-enriched cell preparation, the release of motilin was determined under stimulation with various agents. Carbachol dose-dependently stimulated the release of motilin from its producing cell. Bombesin, morphine, and erythromycin, recognized stimulants for motilin release in vivo, failed to influence the secretion of motilin in vitro. Serotonin, GIP, CCK, pentagastrin, cisapride, neosynephrine, isoproterenol, or muscimol were also ineffective in the in vitro model. The response to carbachol was abolished by atropine but was not affected by somatostatin, serotonin, secretin, CCK, or GIP. These results suggest that muscarinic receptors are present on the motilin cell membrane and that acetylcholine is a major regulator of motilin release.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0196-9781
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
207-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Cholinergic regulation of motilin release from isolated canine intestinal cells.
pubmed:affiliation
André-Viallet Clinical Research Center, Hôpital St-Luc, University of Montreal, Quebec, Canada.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't