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rdf:type |
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lifeskim:mentions |
umls-concept:C0003211,
umls-concept:C0015127,
umls-concept:C0038351,
umls-concept:C0205314,
umls-concept:C0215737,
umls-concept:C0221198,
umls-concept:C0280004,
umls-concept:C0547040,
umls-concept:C0679622,
umls-concept:C1280500,
umls-concept:C1314792
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pubmed:issue |
1
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pubmed:dateCreated |
1993-5-28
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pubmed:abstractText |
1. NS-398 (N-[2-cyclohexyloxy-4-nitrophenyl] methanesulfonamide) is a new non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic effects. 2. The anti-inflammatory potency of NS-398 in rat carrageenin-induced edema was as potent as that of indomethacin and 8 times more potent than diclofenac. In rat adjuvant arthritis, NS-398 showed a therapeutic effect comparable to that seen with loxoprofen but less than that seen with indomethacin and diclofenac. 3. The analgesic potency of NS-398 in rat adjuvant arthritic pain was much the same as that of indomethacin, and was about 3-5 times higher than that of diclofenac and loxoprofen. In the Randall-Selitto method in rats, NS-398 was 2-7 times as potent as loxoprofen, diclofenac and indomethacin. In acetic acid-induced writhing in mice, NS-398 was equipotent to indomethacin and diclofenac. 4. In LPS-induced fever in rats, NS-398 was 1.5-4.5 times as potent as loxoprofen and indomethacin, but less potent than diclofenac. 5. NS-398 produced little gastric ulceration in doses of up to 1000 mg/kg, while reference drugs produced distinct stomach lesions in doses of 10-30 mg/kg. 6. NS-398 inhibited prostaglandin (PG) endoperoxide synthase from sheep seminal vesicle microsomes less potent than that of ibuprofen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Carrageenan,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Diclofenac,
http://linkedlifedata.com/resource/pubmed/chemical/Ibuprofen,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylpropionates,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/loxoprofen
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0306-3623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
105-10
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8482483-Animals,
pubmed-meshheading:8482483-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:8482483-Arthritis, Experimental,
pubmed-meshheading:8482483-Carrageenan,
pubmed-meshheading:8482483-Cyclooxygenase Inhibitors,
pubmed-meshheading:8482483-Diclofenac,
pubmed-meshheading:8482483-Edema,
pubmed-meshheading:8482483-Fever,
pubmed-meshheading:8482483-Ibuprofen,
pubmed-meshheading:8482483-Indomethacin,
pubmed-meshheading:8482483-Male,
pubmed-meshheading:8482483-Nitrobenzenes,
pubmed-meshheading:8482483-Pain,
pubmed-meshheading:8482483-Phenylpropionates,
pubmed-meshheading:8482483-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:8482483-Rats,
pubmed-meshheading:8482483-Rats, Wistar,
pubmed-meshheading:8482483-Stomach Ulcer,
pubmed-meshheading:8482483-Sulfonamides
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pubmed:year |
1993
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pubmed:articleTitle |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
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pubmed:affiliation |
Research Center, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
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