Linked Life Data

8479004

Source:http://linkedlifedata.com/resource/pubmed/id/8479004

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-5-24
pubmed:abstractText
Plasma lidocaine decay after injection was studied in five anaesthetized pigs and fitted to a two compartment open model. Derived pharmacokinetic parameters were employed to rapidly achieve plateau concentrations within 60 min of starting a two stage infusion of lidocaine hydrochloride. Hepatic extraction and clearance of lidocaine at steady state were determined in 10 pigs by transhepatic sampling and measurement of hepatic arterial and portal venous blood flow using perivascular ultrasonic flow probes placed at laparotomy. These data were compared with similar studies performed in man as well as the sheep, dog, monkey and cat. The lidocaine extraction ratio of 0.60 in the pig was found to be similar to that determined by others in man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0140-7783
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8-14
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Lidocaine decay and hepatic extraction in the pig.
pubmed:affiliation
Department of Anesthesiology, Columbia Presbyterian Medical Center, New York, NY 10032.
pubmed:publicationType
Journal Article, Comparative Study