Linked Life Data

8478595

Source:http://linkedlifedata.com/resource/pubmed/id/8478595

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-5-25
pubmed:abstractText
Binding of Staphylococcus aureus to vascular endothelial cells may be an initiating event in the pathogenesis of endovascular infection, particularly infective endocarditis. In this study a competition assay between labeled and unlabeled bacteria was used to identify potential S. aureus-binding determinants on the surface of cultured porcine aortic valve endothelial cells. Concanavalin A inhibited 30% to 40% of the specific binding of S. aureus to membrane-associated components. Concanavalin A affinity chromatography of radiolabeled cell-surface proteins, followed by isolation of S. aureus-binding proteins, identified a 130,000-molecular-weight cell surface protein that may function as an endothelial cell S. aureus receptor. These data suggest that specific binding of S. aureus to cardiac valve endothelial cells is mediated in part by a 130 kd mannose-containing glycoprotein.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-2143
pubmed:author
pubmed:issnType
Print
pubmed:volume
121
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
675-82
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Staphylococcus aureus binding to cardiac endothelial cells is partly mediated by a 130 kilodalton glycoprotein.
pubmed:affiliation
Department of Pediatrics, Mayo Clinic/Foundation, Rochester, MN 55905.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't