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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
3
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pubmed:dateCreated |
1993-5-25
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pubmed:abstractText |
The neuronal Na(+)- and Cl(-)-dependent transporter for the neurotransmitter noradrenaline (NA) is the primary target for the tricyclic antidepressant desipramine. The NA-transporter belongs to a new gene family of structurally related Na(+)- and Cl(-)-dependent neurotransmitter transporters. In this study, the chromosomal localization for the gene encoding the human NA-transporter (h-NAT) was determined. By hybridization of a panel of somatic cell hybrids and by fluorescent in situ hybridization to metaphase chromosomes, the hNAT gene was localized on chromosome 16q12.2. In addition, evidence is presented for an intron-exon structure of the gene.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0340-6717
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
91
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pubmed:geneSymbol |
hNAT
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
278-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8478011-Animals,
pubmed-meshheading:8478011-Antidepressive Agents, Tricyclic,
pubmed-meshheading:8478011-Carrier Proteins,
pubmed-meshheading:8478011-Chromosome Mapping,
pubmed-meshheading:8478011-Chromosomes, Human, Pair 16,
pubmed-meshheading:8478011-Humans,
pubmed-meshheading:8478011-Hybrid Cells,
pubmed-meshheading:8478011-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8478011-Norepinephrine,
pubmed-meshheading:8478011-Norepinephrine Plasma Membrane Transport Proteins,
pubmed-meshheading:8478011-Rodentia,
pubmed-meshheading:8478011-Symporters,
pubmed-meshheading:8478011-Tumor Cells, Cultured
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pubmed:year |
1993
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|
pubmed:articleTitle |
Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter.
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pubmed:affiliation |
Institut für Pharmakologie und Toxikologie, Universität Bonn, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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