| pubmed-article:8477878 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8477878 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:8477878 | lifeskim:mentions | umls-concept:C0011849 | lld:lifeskim |
| pubmed-article:8477878 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8477878 | lifeskim:mentions | umls-concept:C0338656 | lld:lifeskim |
| pubmed-article:8477878 | lifeskim:mentions | umls-concept:C0020615 | lld:lifeskim |
| pubmed-article:8477878 | lifeskim:mentions | umls-concept:C0009566 | lld:lifeskim |
| pubmed-article:8477878 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8477878 | lifeskim:mentions | umls-concept:C0034897 | lld:lifeskim |
| pubmed-article:8477878 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:8477878 | lifeskim:mentions | umls-concept:C2926735 | lld:lifeskim |
| pubmed-article:8477878 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8477878 | pubmed:dateCreated | 1993-5-24 | lld:pubmed |
| pubmed-article:8477878 | pubmed:abstractText | To examine the long-term effects of recurrent severe hypoglycaemia and other biomedical complications on mental efficiency, a battery of cognitive tests was administered to 142 Type 1 (insulin-dependent) diabetic adult patients (age 33.5 +/- 5.6 years; mean +/- SD) and 100 demographically similar non-diabetic control subjects. All diabetic subjects had been diagnosed before the age of 17 years. Diabetic subjects with one or more complications (distal symmetrical polyneuropathy; advanced background or proliferative retinopathy; overt nephropathy; one or more episodes of severe hypoglycaemia) performed significantly (p < 0.001) more poorly than non-diabetic control subjects on tests requiring sustained attention, rapid analysis of visuospatial detail, and hand eye co-ordination. Regression analyses indicated that the best biomedical predictor of cognitive test performance was a diagnosis of polyneuropathy. Although severe recurrent hypoglycaemia was not associated with performance on any test, the neuropathy x recurrent hypoglycaemia interaction term was significant. These results suggest that in adults with Type 1 diabetes of long duration, recurrent hypoglycaemia does not appear to influence cognitive performance directly, but may interact with neuropathy to exaggerate or otherwise magnify the extent of neurobehavioural dysfunction. | lld:pubmed |
| pubmed-article:8477878 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8477878 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8477878 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8477878 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8477878 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8477878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8477878 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8477878 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8477878 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8477878 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:8477878 | pubmed:author | pubmed-author:WilliamsT MTM | lld:pubmed |
| pubmed-article:8477878 | pubmed:author | pubmed-author:OrchardT JTJ | lld:pubmed |
| pubmed-article:8477878 | pubmed:author | pubmed-author:FinegoldD NDN | lld:pubmed |
| pubmed-article:8477878 | pubmed:author | pubmed-author:RyanC MCM | lld:pubmed |
| pubmed-article:8477878 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8477878 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:8477878 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8477878 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8477878 | pubmed:pagination | 329-34 | lld:pubmed |
| pubmed-article:8477878 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8477878 | pubmed:meshHeading | pubmed-meshheading:8477878-... | lld:pubmed |
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| pubmed-article:8477878 | pubmed:meshHeading | pubmed-meshheading:8477878-... | lld:pubmed |
| pubmed-article:8477878 | pubmed:meshHeading | pubmed-meshheading:8477878-... | lld:pubmed |
| pubmed-article:8477878 | pubmed:meshHeading | pubmed-meshheading:8477878-... | lld:pubmed |
| pubmed-article:8477878 | pubmed:meshHeading | pubmed-meshheading:8477878-... | lld:pubmed |
| pubmed-article:8477878 | pubmed:meshHeading | pubmed-meshheading:8477878-... | lld:pubmed |
| pubmed-article:8477878 | pubmed:meshHeading | pubmed-meshheading:8477878-... | lld:pubmed |
| pubmed-article:8477878 | pubmed:meshHeading | pubmed-meshheading:8477878-... | lld:pubmed |
| pubmed-article:8477878 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8477878 | pubmed:articleTitle | Cognitive dysfunction in adults with type 1 (insulin-dependent) diabetes mellitus of long duration: effects of recurrent hypoglycaemia and other chronic complications. | lld:pubmed |
| pubmed-article:8477878 | pubmed:affiliation | Department of Psychiatry, University of Pittsburgh, School of Medicine, Pennsylvania. | lld:pubmed |
| pubmed-article:8477878 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8477878 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8477878 | lld:pubmed |
