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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1993-5-24
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pubmed:abstractText |
To examine the long-term effects of recurrent severe hypoglycaemia and other biomedical complications on mental efficiency, a battery of cognitive tests was administered to 142 Type 1 (insulin-dependent) diabetic adult patients (age 33.5 +/- 5.6 years; mean +/- SD) and 100 demographically similar non-diabetic control subjects. All diabetic subjects had been diagnosed before the age of 17 years. Diabetic subjects with one or more complications (distal symmetrical polyneuropathy; advanced background or proliferative retinopathy; overt nephropathy; one or more episodes of severe hypoglycaemia) performed significantly (p < 0.001) more poorly than non-diabetic control subjects on tests requiring sustained attention, rapid analysis of visuospatial detail, and hand eye co-ordination. Regression analyses indicated that the best biomedical predictor of cognitive test performance was a diagnosis of polyneuropathy. Although severe recurrent hypoglycaemia was not associated with performance on any test, the neuropathy x recurrent hypoglycaemia interaction term was significant. These results suggest that in adults with Type 1 diabetes of long duration, recurrent hypoglycaemia does not appear to influence cognitive performance directly, but may interact with neuropathy to exaggerate or otherwise magnify the extent of neurobehavioural dysfunction.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0012-186X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
329-34
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8477878-Adult,
pubmed-meshheading:8477878-Blood Glucose,
pubmed-meshheading:8477878-Cognition Disorders,
pubmed-meshheading:8477878-Diabetes Mellitus, Type 1,
pubmed-meshheading:8477878-Diabetic Neuropathies,
pubmed-meshheading:8477878-Diabetic Retinopathy,
pubmed-meshheading:8477878-Female,
pubmed-meshheading:8477878-Hemoglobin A, Glycosylated,
pubmed-meshheading:8477878-Humans,
pubmed-meshheading:8477878-Hypoglycemia,
pubmed-meshheading:8477878-Intelligence Tests,
pubmed-meshheading:8477878-Male,
pubmed-meshheading:8477878-Neuropsychological Tests
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pubmed:year |
1993
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pubmed:articleTitle |
Cognitive dysfunction in adults with type 1 (insulin-dependent) diabetes mellitus of long duration: effects of recurrent hypoglycaemia and other chronic complications.
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pubmed:affiliation |
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pennsylvania.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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