Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-5-24
pubmed:abstractText
A community-based population sample of 14,379 North American children and adults aged from birth to 75 years with normal ECG was used to investigate functional properties of 13 QT prediction formulas over a wide range of heart rates (HR) in normal sinus rhythm. QT measurements were made by a computer program from simultaneously sampled standard 12-lead or orthogonal XYZ leads and all QT measurements were visually verified using a high-resolution display terminal. New concepts of QT rate sensitivity (dQT/dHR) and maximum predicted QT after a long pause (QTmax) are introduced. Drastically diverging functional behavior is documented for different QT prediction formulas regarding QT rate sensitivity and QTmax. The simplest formula for predicted QT (QTp) meeting reasonable physiological constraints regarding QTmax and functional behavior of QT rate sensitivity while producing the best QT prediction accuracy was a function with only one independently adjusted parameter (QTmax) of the form: QTp = QTmax/(1 + 0.01HR), with QTmax = 656 ms. This formula also suggests that QT rate sensitivity is inversely proportional to the square of HR and that individual values of QTmax can be predicted from ambulatory or exercise ECGs using the formula QTmax = 2 x QT100, where QT100 is QT at HR = 100/min.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0010-4809
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
188-204
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:8477589-Adolescent, pubmed-meshheading:8477589-Adult, pubmed-meshheading:8477589-Aged, pubmed-meshheading:8477589-Child, pubmed-meshheading:8477589-Child, Preschool, pubmed-meshheading:8477589-Confidence Intervals, pubmed-meshheading:8477589-Data Interpretation, Statistical, pubmed-meshheading:8477589-Electrocardiography, pubmed-meshheading:8477589-Female, pubmed-meshheading:8477589-Heart Rate, pubmed-meshheading:8477589-Humans, pubmed-meshheading:8477589-Infant, pubmed-meshheading:8477589-Infant, Newborn, pubmed-meshheading:8477589-Male, pubmed-meshheading:8477589-Middle Aged, pubmed-meshheading:8477589-North America, pubmed-meshheading:8477589-Predictive Value of Tests, pubmed-meshheading:8477589-Reference Values, pubmed-meshheading:8477589-Sensitivity and Specificity
pubmed:year
1993
pubmed:articleTitle
Functional characteristics of QT prediction formulas. The concepts of QTmax and QT rate sensitivity.
pubmed:affiliation
University of Alberta, Edmonton, Canada.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't