Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1993-5-18
|
pubmed:abstractText |
Effect of K- and L- molecular orbital regions on expression of antiplasmid and carcinogenic activity was studied with various benz[c]acridine derivatives, tricyclic compounds (acridine orange, phenothiazines) and dibenzoazepine (imipramine). Antiplasmid compounds showed the out-of-phase of molecular orbital in the L-region. On the other hand, mutagenic and carcinogenic compounds showed the out-of-phase in the L-region, and their energy was accumulated in the K-region of the molecular orbitals. The present study suggests that the molecular orbitals responsible for the expression of antiplasmid and carcinogenic effects might be basically different.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0250-7005
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
263-6
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:8476222-Acridines,
pubmed-meshheading:8476222-Carcinogens,
pubmed-meshheading:8476222-Chemistry, Physical,
pubmed-meshheading:8476222-Escherichia coli,
pubmed-meshheading:8476222-Physicochemical Phenomena,
pubmed-meshheading:8476222-Plasmids,
pubmed-meshheading:8476222-Structure-Activity Relationship
|
pubmed:articleTitle |
Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds.
|
pubmed:affiliation |
Faculty of Medicine, Albert Szent-Gyorgyi Medical University, Szeged, Hungary.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|