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pubmed-article:8475965pubmed:abstractTextWe tested a new hormone replacement formulation based on the hypothesis that interrupted administration of progestin in the presence of continuous estrogen would result in receptor up-regulation and resensitization of target tissues to both estrogen and progestin. As a result, symptom control might be possible with lower doses of steroids and in the absence of withdrawal bleeding.lld:pubmed
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pubmed-article:8475965pubmed:articleTitleEstrogen and interrupted progestin: a new concept for menopausal hormone replacement therapy.lld:pubmed
pubmed-article:8475965pubmed:affiliationDepartment of Obstetrics and Gynecology, University of Toronto, Ontario, Canada.lld:pubmed
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pubmed-article:8475965pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed