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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1993-5-18
|
| pubmed:abstractText |
Focal intracerebral lesions were biopsied stereotactically in 23 adult HIV-infected patients, the main indication for which was the failure to respond to anti-toxoplasma treatment. A cerebral disease was the initial or main complaint in 19 of them. In 22 of 25 stereotactic approaches, a clear-cut morphological diagnosis could be established (9 primary brain lymphoma, 7 necrotizing toxoplasma encephalitis, 5 progressive multifocal leukoencephalopathy, 1 HIV encephalitis, 3 unspecific tissue changes). In 7 of 8 deceased patients, autopsy confirmed the bioptical diagnosis. The high diagnostic yield was related to the strategy of the stereotactic method and the sample size (3 to 4 consecutive samples along the stereotactic track including the marginal zones, 1 cm long tissue cylinders). Formalin fixation and paraffin embedding of the samples provide the possibility of serial sections and special stainings (immunohistochemistry, in-situ hybridization) and kill the HIV. Stereotactic brain biopsy is a highly accurate diagnostic tool to ascertain the nature of focal intracerebral lesions in selected AIDS patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0001-6314
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
87
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
228-33
|
| pubmed:dateRevised |
2006-8-16
|
| pubmed:meshHeading |
pubmed-meshheading:8475695-AIDS Dementia Complex,
pubmed-meshheading:8475695-AIDS-Related Opportunistic Infections,
pubmed-meshheading:8475695-Adult,
pubmed-meshheading:8475695-Biopsy, Needle,
pubmed-meshheading:8475695-Brain,
pubmed-meshheading:8475695-Brain Neoplasms,
pubmed-meshheading:8475695-Female,
pubmed-meshheading:8475695-HIV Seropositivity,
pubmed-meshheading:8475695-HIV-1,
pubmed-meshheading:8475695-Humans,
pubmed-meshheading:8475695-Leukoencephalopathy, Progressive Multifocal,
pubmed-meshheading:8475695-Lymphoma, AIDS-Related,
pubmed-meshheading:8475695-Male,
pubmed-meshheading:8475695-Neuroglia,
pubmed-meshheading:8475695-Neurons,
pubmed-meshheading:8475695-Stereotaxic Techniques,
pubmed-meshheading:8475695-Tomography, X-Ray Computed,
pubmed-meshheading:8475695-Toxoplasmosis, Cerebral
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
The stereotactic biopsy diagnosis of focal intracerebral lesions in AIDS patients.
|
| pubmed:affiliation |
Department of Neurosurgery, University of Munich, Germany.
|
| pubmed:publicationType |
Journal Article
|