Linked Life Data

8473687

Source:http://linkedlifedata.com/resource/pubmed/id/8473687

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-5-17
pubmed:abstractText
The gastrointestinal tract represents an organ system that is characterized by rapid proliferation and by cells that demonstrate differentiation from immature stem cells to terminal differentiated mature cells. Aging gastrointestinal tissues illustrate markedly different phenomena from aged post-mitotic cells. Contrary to generally held prejudices, a state of hyperproliferation, not hypoproliferation, occurs in the epithelial cells of the stomach, the small intestine, and the large intestine of stable-fed, aged rodents when compared to young mature rodents. Furthermore, abnormalities of proliferative and differentiation responses become evident when gastrointestinal tissues are stimulated by injury, or by starvation and refeeding. We speculate that such changes in proliferation and differentiation expose aging gastrointestinal epithelial cells to genotoxic effects that may increase the susceptibility to gastrointestinal cancers.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-1422
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
B43-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Gastrointestinal proliferation and aging.
pubmed:affiliation
Division of Gastroenterology, St. Luke's-Roosevelt Hospital Center, New York, NY 10025.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't