| pubmed-article:8473291 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8473291 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
| pubmed-article:8473291 | lifeskim:mentions | umls-concept:C0032043 | lld:lifeskim |
| pubmed-article:8473291 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
| pubmed-article:8473291 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:8473291 | lifeskim:mentions | umls-concept:C1337049 | lld:lifeskim |
| pubmed-article:8473291 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8473291 | lifeskim:mentions | umls-concept:C1517488 | lld:lifeskim |
| pubmed-article:8473291 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:8473291 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8473291 | pubmed:dateCreated | 1993-5-14 | lld:pubmed |
| pubmed-article:8473291 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8473291 | pubmed:abstractText | Five members of the human growth hormone (GH) gene family are located at a single locus on chromosome 17. Growth hormone is expressed in the pituitary under the control of the tissue-specific factor Pit 1/GHF-1, and chorionic somatomammotropin (CS) -A, -B, and -L, as well as placental GH variant, are expressed specifically in the placental syncytiotrophoblast. Despite this specificity in vivo, the CS-A promoter can bind Pit 1/GHF-1 and allow CS-A promoter activity in pituitary tumor cells after gene transfer. We have identified and characterized PSF sequences associated with only the placental members in the GH/CS locus which repress placental promoter activity > 90% in transfected pituitary cells. These sequences do not significantly affect promoter function in placental cells after gene transfer. Repressor activity correlates with binding of protein at two sites (PSF-A and PSF-B) with pituitary, but not placental, nuclear extracts. Competition studies suggest an interaction between PSF and Pit 1/GHF-1 proteins. These results indicate that PSF protein can repress CS-A promoter activity in a tissue-specific manner in vitro and provide a possible mechanism by which expression of placental members of the GH family are inhibited in the pituitary in vivo. | lld:pubmed |
| pubmed-article:8473291 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8473291 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8473291 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8473291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8473291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8473291 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8473291 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8473291 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8473291 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8473291 | pubmed:author | pubmed-author:CattiniP APA | lld:pubmed |
| pubmed-article:8473291 | pubmed:author | pubmed-author:NachtigalM... | lld:pubmed |
| pubmed-article:8473291 | pubmed:author | pubmed-author:NickelB EBE | lld:pubmed |
| pubmed-article:8473291 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8473291 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:8473291 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:8473291 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8473291 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8473291 | pubmed:pagination | 8473-9 | lld:pubmed |
| pubmed-article:8473291 | pubmed:dateRevised | 2010-9-21 | lld:pubmed |
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| pubmed-article:8473291 | pubmed:meshHeading | pubmed-meshheading:8473291-... | lld:pubmed |
| pubmed-article:8473291 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8473291 | pubmed:articleTitle | Pituitary-specific repression of placental members of the human growth hormone gene family. A possible mechanism for locus regulation. | lld:pubmed |
| pubmed-article:8473291 | pubmed:affiliation | Department of Physiology, University of Manitoba, Winnipeg, Canada. | lld:pubmed |
| pubmed-article:8473291 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8473291 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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