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The acuJ mutant of Aspergillus nidulans has been shown to lack carnitine acetyltransferase (CAT) activity when grown under conditions where this activity is readily detectable in wild-type strains. Revertants selected for growth on acetate recover CAT activity and the ability to grow on long-chain fatty acids. When growing on carbon sources such as sucrose, cytosolic acetyl coenzyme A was generated by adenosine triphosphate (ATP):citrate lyase.
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