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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-5-19
|
| pubmed:abstractText |
The neurohypophyseal peptide hormone arginine-vasopressin functions as a neuropeptide in several brain areas in addition to its role as a posterior pituitary hormone. Several studies indicate that arginine-vasopressin and arginine-vasopressin receptors appear early in the infant rat brain. To determine if arginine-vasopressin receptors in the infant were responsive to exogenous peptides, we compared the behavioral effects of central or peripheral administration of arginine-vasopressin, arginine vasotocin, the oxytocin precursor oxytocin-Gly-Lys-Arg, and arginine-vasopressin receptor antagonists in socially isolated rat pups. Central administration of arginine-vasopressin decreased the number of rat pup ultrasonic vocalizations, reduced locomotor activity and decreased the latency to express a response to negative geotaxis. Temperature was also reduced at all doses tested. Co-administration of arginine-vasopressin and receptor antagonists suggested that changes in vocal behavior were mediated by the V1 receptor subtype. Changes in core temperature appeared to be mediated by a V2 receptor subtype. Peripheral arginine-vasopressin administration increased calling and decreased core body temperature. Neither effect was blocked by central receptor antagonist administration. The results are consistent with the hypothesis that arginine-vasopressin receptors in the infant rat brain are functional.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0014-2999
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
16
|
| pubmed:volume |
233
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
101-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8472738-Animals,
pubmed-meshheading:8472738-Animals, Newborn,
pubmed-meshheading:8472738-Arginine Vasopressin,
pubmed-meshheading:8472738-Body Temperature Regulation,
pubmed-meshheading:8472738-Injections, Intraventricular,
pubmed-meshheading:8472738-Injections, Subcutaneous,
pubmed-meshheading:8472738-Motor Activity,
pubmed-meshheading:8472738-Rats,
pubmed-meshheading:8472738-Rats, Sprague-Dawley,
pubmed-meshheading:8472738-Receptors, Vasopressin,
pubmed-meshheading:8472738-Social Isolation,
pubmed-meshheading:8472738-Vasotocin,
pubmed-meshheading:8472738-Vocalization, Animal
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Effects of central vasopressin administration to infant rats.
|
| pubmed:affiliation |
Unit Develop Biopsych, NIMH, NIHAC, Poolesville, MD 20837.
|
| pubmed:publicationType |
Journal Article
|