Linked Life Data

8470687

Source:http://linkedlifedata.com/resource/pubmed/id/8470687

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-5-13
pubmed:abstractText
The stability of procainamide hydrochloride in two oral syrups, one prepared with sucrose and the other with maltitol, was studied. A syrup containing powder from 500-mg procainamide hydrochloride capsules, simple sucrose syrup, and other additives was prepared; the theoretical initial concentration of procainamide hydrochloride was 50 mg/mL. Three samples each were stored at 40, 50, 60, and 70 degrees C. Drug concentration was measured with high-performance liquid chromatography at times ranging from 2 to 107 days. In a second study, a syrup containing powder from 500-mg procainamide hydrochloride capsules, a maltitol-based syrup vehicle, and other additives was prepared; the theoretical initial drug concentration was 50 mg/mL. Three samples each were stored at 40, 50, 60, and 70 degrees C. Drug concentration was measured at times ranging from 7 to 187 days. For the sucrose-based syrup, there was apparent first-order degradation of procainamide hydrochloride at all temperatures. An Arrhenius plot was used to calculate a shelf life of the syrup of 456 days at 25 degrees C. Most samples turned brown over time, and pH values were constant. For the maltitol-based syrup, drug degradation appeared to be biphasic; an initial period during which concentrations remained at nearly 100% was followed by apparent first-order degradation. Arrhenius plotting gave a shelf life of 97 days at 25 degrees C. Most samples turned brown over time, and pHs remained constant. Arrhenius plots indicated that in a maltitol-based oral syrup, procainamide hydrochloride was more stable than in a sucrose-based syrup when the storage temperature was above 37 degrees C.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9289
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
693-8
pubmed:dateRevised
2000-12-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Stability of procainamide hydrochloride syrups compounded from capsules.
pubmed:affiliation
Department of Pharmacy Practice, University of Toledo, OH.
pubmed:publicationType
Journal Article