|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5105
|
|
pubmed:dateCreated |
1993-5-10
|
|
pubmed:abstractText |
Cells maintain the integrity of their genome through an intricate network of repair systems that recognize and remove lesions from DNA. The only known site-directed recombination process in vertebrates is the V(D)J recombination of lymphocyte antigen receptor genes. A large panel of cell lines deficient in DNA repair were tested for the ability to perform V(D)J recombination after introduction of the RAG-1 and RAG-2 genes. Two mutants failed to generate normal V(D)J recombination, and further analysis provided evidence for two distinct nonlymphoid-specific genes that encode factors involved in both DNA repair and V(D)J recombination.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
9
|
|
pubmed:volume |
260
|
|
pubmed:geneSymbol |
RAG-1,
RAG-2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
207-10
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:8469973-Animals,
pubmed-meshheading:8469973-Base Sequence,
pubmed-meshheading:8469973-CHO Cells,
pubmed-meshheading:8469973-Cell Line,
pubmed-meshheading:8469973-Cricetinae,
pubmed-meshheading:8469973-DNA Nucleotidyltransferases,
pubmed-meshheading:8469973-DNA Repair,
pubmed-meshheading:8469973-Gene Rearrangement, T-Lymphocyte,
pubmed-meshheading:8469973-Genes, RAG-1,
pubmed-meshheading:8469973-Immunoglobulin Heavy Chains,
pubmed-meshheading:8469973-Molecular Sequence Data,
pubmed-meshheading:8469973-Mutation,
pubmed-meshheading:8469973-Receptors, Antigen, T-Cell,
pubmed-meshheading:8469973-Recombination, Genetic,
pubmed-meshheading:8469973-VDJ Recombinases
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Impairment of V(D)J recombination in double-strand break repair mutants.
|
|
pubmed:affiliation |
Howard Hughes Medical Institute, Children's Hospital, Boston, MA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
