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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1993-5-11
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pubmed:abstractText |
1. The degradation of the bone matrix proteins osteocalcin, osteonectin and alpha 2HS-glycoprotein by human cathepsins B and L and human osteoclastoma cathepsins has been investigated. 2. Intermediate degradation products (M(r) > 12 kDa) were not observed during the digestion of alpha 2HS-glycoprotein and osteonectin by cathepsins B and L although they were observed with some of the osteoclastoma cathepsins. Most of the osteoclastoma cathepsins were capable of degrading these two proteins to small peptides at comparable rates. 3. Each cathepsin produced a different pattern of osteocalcin degradation products. 4. The extensive range of non-collagenous proteins in bone matrix may necessitate the production by osteoclasts of cathepsins with different specificities during bone resorption.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AHSG protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CTSL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin B,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin L,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsins,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Endopeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Osteonectin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-2-HS-Glycoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0020-711X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
545-50
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8467955-Blood Proteins,
pubmed-meshheading:8467955-Cathepsin B,
pubmed-meshheading:8467955-Cathepsin L,
pubmed-meshheading:8467955-Cathepsins,
pubmed-meshheading:8467955-Chromatography, High Pressure Liquid,
pubmed-meshheading:8467955-Cysteine Endopeptidases,
pubmed-meshheading:8467955-Endopeptidases,
pubmed-meshheading:8467955-Giant Cell Tumors,
pubmed-meshheading:8467955-Humans,
pubmed-meshheading:8467955-Kinetics,
pubmed-meshheading:8467955-Osteocalcin,
pubmed-meshheading:8467955-Osteoclasts,
pubmed-meshheading:8467955-Osteonectin,
pubmed-meshheading:8467955-Peptide Fragments,
pubmed-meshheading:8467955-Tumor Cells, Cultured,
pubmed-meshheading:8467955-alpha-2-HS-Glycoprotein
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pubmed:year |
1993
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pubmed:articleTitle |
Degradation of bone matrix proteins by osteoclast cathepsins.
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pubmed:affiliation |
Department of Hisopathology, St George's Hospital Medical School, London, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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