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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-5-7
|
| pubmed:abstractText |
The effect of hemodilution, with alpha-alpha cross-linked hemoglobin (DCLHb), on brain injury and edema was assessed after temporary middle cerebral artery occlusion in rats. Injury was analyzed with 2,3,5-triphenyltetrazolium chloride (TTC) stain and edema by microgravimety. Part A: DCLHb was given to maintain one of the following hematocrits (Hct) and normotension: 1) 45/Hct, 2) 30/Hct, 3) 16/Hct, or 4) 9/Hct. Brain injury (% of ischemic hemisphere, mean +/- SD) was less in the 30/Hct group (31 +/- 4) versus the 45/Hct group (42 +/- 5); and in the 16/Hct (20 +/- 3) and 9/Hct (19 +/- 4) groups versus the 45/Hct and 30/Hct groups. Edema was less in the hemodiluted groups versus the 45/Hct group. Part B: DCLHb was given to maintain one of the following hematocrits and hyper (HTN)-or normotension (Norm): 1) 45/Norm, 2) 30/Norm, 3) 30/HTN, 4) 16/Norm, or 5) 16/HTN. In hematocrit matched groups hypertension decreased brain injury (30/HTN-24 +/- 2 < 30/Norm-34 +/- 4; and 16/HTN-17 +/- 3 < 16/Norm-24 +/- 4). Edema was not effected by hypertension. These results suggest that hemodilution with DCLHb decreases focal ischemic injury, and is most effective when given in a manner that induces hypertension.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0317-1671
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
30-6
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8467426-Animals,
pubmed-meshheading:8467426-Blood Pressure,
pubmed-meshheading:8467426-Brain Edema,
pubmed-meshheading:8467426-Brain Injuries,
pubmed-meshheading:8467426-Brain Ischemia,
pubmed-meshheading:8467426-Dose-Response Relationship, Drug,
pubmed-meshheading:8467426-Hematocrit,
pubmed-meshheading:8467426-Hemodilution,
pubmed-meshheading:8467426-Hemoglobins,
pubmed-meshheading:8467426-Male,
pubmed-meshheading:8467426-Rats,
pubmed-meshheading:8467426-Rats, Inbred SHR,
pubmed-meshheading:8467426-Specific Gravity
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Focal cerebral ischemia in rats: effect of hemodilution with alpha-alpha cross-linked hemoglobin on brain injury and edema.
|
| pubmed:affiliation |
Department of Anesthesiology, Loma Linda University, California 92354.
|
| pubmed:publicationType |
Journal Article
|