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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1993-5-6
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pubmed:abstractText |
Albendazole, a broad spectrum anthelmintic recently shown to be active in vitro against Giardia duodenalis, was given at 4 different dosages and compared with metronidazole in the treatment of children in Bangladesh infected with Giardia. Three stools were collected over 10 d after treatment and examined microscopically. Albendazole was found to be effective: single doses of either 600 mg (n = 103) or 800 mg (n = 114) successfully treated 62% and 75% of infections, respectively; 400 mg given either once a day for 3 d (n = 116) or for 5 d (n = 115) successfully treated 81% and 95% of all infections, respectively. Albendazole given daily at 400 mg for 5 d was as effective as metronidazole, which cured 97% of infections (n = 230). Albendazole may thus be an alternative treatment for infections with Giardia, while the moderate efficacy of single doses may provide a benefit in addition to its effects on several species of intestinal helminths.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0035-9203
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8465408-Albendazole,
pubmed-meshheading:8465408-Animals,
pubmed-meshheading:8465408-Bangladesh,
pubmed-meshheading:8465408-Child,
pubmed-meshheading:8465408-Child, Preschool,
pubmed-meshheading:8465408-Dose-Response Relationship, Drug,
pubmed-meshheading:8465408-Double-Blind Method,
pubmed-meshheading:8465408-Drug Administration Schedule,
pubmed-meshheading:8465408-Duodenal Diseases,
pubmed-meshheading:8465408-Feces,
pubmed-meshheading:8465408-Giardia lamblia,
pubmed-meshheading:8465408-Giardiasis,
pubmed-meshheading:8465408-Humans,
pubmed-meshheading:8465408-Metronidazole,
pubmed-meshheading:8465408-Treatment Outcome
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pubmed:articleTitle |
Albendazole as a treatment for infections with Giardia duodenalis in children in Bangladesh.
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pubmed:affiliation |
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
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