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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1993-5-4
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pubmed:databankReference |
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pubmed:abstractText |
Mutants of Bordetella pertussis which are defective in secretion of pertussis toxin were isolated and characterized. The region of the B. pertussis chromosome identified by mutagenesis as playing a role in transport of pertussis toxin was sequenced. Analysis of this region revealed eight open reading frames, seven of which predict a protein exhibiting homology with one of the VirB proteins of Agrobacterium tumefaciens, which are involved in the transport of the T-DNA molecule across bacterial and plant membranes. Thus a set of accessory proteins are most likely involved in the secretion of pertussis toxin, and these proteins appear to be members of a family of proteins involved in the secretion of macromolecules from bacteria.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-1831965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-1987161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-2050404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-2194232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-2370849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-2465274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-2542937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-2569447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-2572561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-2837739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-2873570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-2903126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-3071244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-3113327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-3281947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-3430596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-3704651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-6260575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-6293544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-6542069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-6546423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-6682833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8464913-6954463
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2970-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8464913-Agrobacterium tumefaciens,
pubmed-meshheading:8464913-Amino Acid Sequence,
pubmed-meshheading:8464913-Bacterial Proteins,
pubmed-meshheading:8464913-Base Sequence,
pubmed-meshheading:8464913-Bordetella pertussis,
pubmed-meshheading:8464913-Chromosomes, Bacterial,
pubmed-meshheading:8464913-DNA, Bacterial,
pubmed-meshheading:8464913-Kinetics,
pubmed-meshheading:8464913-Macromolecular Substances,
pubmed-meshheading:8464913-Molecular Sequence Data,
pubmed-meshheading:8464913-Mutagenesis,
pubmed-meshheading:8464913-Open Reading Frames,
pubmed-meshheading:8464913-Operon,
pubmed-meshheading:8464913-Pertussis Toxin,
pubmed-meshheading:8464913-Phenotype,
pubmed-meshheading:8464913-Sequence Homology, Amino Acid,
pubmed-meshheading:8464913-Virulence Factors,
pubmed-meshheading:8464913-Virulence Factors, Bordetella
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pubmed:year |
1993
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pubmed:articleTitle |
Molecular characterization of an operon required for pertussis toxin secretion.
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pubmed:affiliation |
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond 23298.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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