| pubmed-article:8462848 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8462848 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:8462848 | lifeskim:mentions | umls-concept:C1367886 | lld:lifeskim |
| pubmed-article:8462848 | lifeskim:mentions | umls-concept:C0015744 | lld:lifeskim |
| pubmed-article:8462848 | lifeskim:mentions | umls-concept:C2911691 | lld:lifeskim |
| pubmed-article:8462848 | lifeskim:mentions | umls-concept:C0013057 | lld:lifeskim |
| pubmed-article:8462848 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:8462848 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:8462848 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:8462848 | pubmed:dateCreated | 1993-5-6 | lld:pubmed |
| pubmed-article:8462848 | pubmed:abstractText | In Caenorhabditis elegans, sex determination and dosage compensation are coordinately controlled through a group of genes that respond to the primary sex determination signal. Here we describe a new gene, sdc-3, that also controls these processes. In contrast to previously described genes, the sex determination and dosage compensation activities of sdc-3 are separately mutable, indicating that they function independently. Paradoxically, the sdc-3 null phenotype fails to reveal the role of sdc-3 in sex determination: sdc-3 null mutations that lack both activities disrupt dosage compensation but cause no overt sexual transformation. We demonstrate that the dosage compensation defect of sdc-3 null alleles suppresses their sex determination defect. This self-suppression phenomenon provides a striking example of how a disruption in dosage compensation can affect sexual fate. We propose that the suppression occurs via a feedback mechanism that acts at an early regulatory step in the sex determination pathway to promote proper sexual identity. | lld:pubmed |
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| pubmed-article:8462848 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8462848 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8462848 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8462848 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:8462848 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:8462848 | pubmed:author | pubmed-author:MeyerB JBJ | lld:pubmed |
| pubmed-article:8462848 | pubmed:author | pubmed-author:KleinR DRD | lld:pubmed |
| pubmed-article:8462848 | pubmed:author | pubmed-author:PlenefischJ... | lld:pubmed |
| pubmed-article:8462848 | pubmed:author | pubmed-author:DeLongLL | lld:pubmed |
| pubmed-article:8462848 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8462848 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:8462848 | pubmed:geneSymbol | her-1 | lld:pubmed |
| pubmed-article:8462848 | pubmed:geneSymbol | sdc-3 | lld:pubmed |
| pubmed-article:8462848 | pubmed:geneSymbol | dpy-29 | lld:pubmed |
| pubmed-article:8462848 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8462848 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8462848 | pubmed:pagination | 875-96 | lld:pubmed |
| pubmed-article:8462848 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:8462848 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8462848 | pubmed:articleTitle | Feedback control of sex determination by dosage compensation revealed through Caenorhabditis elegans sdc-3 mutations. | lld:pubmed |
| pubmed-article:8462848 | pubmed:affiliation | Department of Molecular and Cell Biology, University of California, Berkeley 94720. | lld:pubmed |
| pubmed-article:8462848 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8462848 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8462848 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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