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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1993-5-6
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pubmed:abstractText |
In Caenorhabditis elegans, sex determination and dosage compensation are coordinately controlled through a group of genes that respond to the primary sex determination signal. Here we describe a new gene, sdc-3, that also controls these processes. In contrast to previously described genes, the sex determination and dosage compensation activities of sdc-3 are separately mutable, indicating that they function independently. Paradoxically, the sdc-3 null phenotype fails to reveal the role of sdc-3 in sex determination: sdc-3 null mutations that lack both activities disrupt dosage compensation but cause no overt sexual transformation. We demonstrate that the dosage compensation defect of sdc-3 null alleles suppresses their sex determination defect. This self-suppression phenomenon provides a striking example of how a disruption in dosage compensation can affect sexual fate. We propose that the suppression occurs via a feedback mechanism that acts at an early regulatory step in the sex determination pathway to promote proper sexual identity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-11813735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-1369741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-13764598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-1695712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-1996090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-2027384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-2030730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-2100265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-2109831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-2158860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-2184942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-2338245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-2374589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-2759421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-2917714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-292825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-295035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3071248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3123218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3137120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3167975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3220248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3396870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3428573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3503722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3666440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3678829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3779843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-3935325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-4366476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-6537930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8462848-8431944
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
133
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pubmed:geneSymbol |
dpy-29,
her-1,
sdc-3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
875-96
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8462848-Alleles,
pubmed-meshheading:8462848-Animals,
pubmed-meshheading:8462848-Caenorhabditis elegans,
pubmed-meshheading:8462848-Caenorhabditis elegans Proteins,
pubmed-meshheading:8462848-DNA-Binding Proteins,
pubmed-meshheading:8462848-Dosage Compensation, Genetic,
pubmed-meshheading:8462848-Feedback,
pubmed-meshheading:8462848-Female,
pubmed-meshheading:8462848-Genes, Regulator,
pubmed-meshheading:8462848-Helminth Proteins,
pubmed-meshheading:8462848-Male,
pubmed-meshheading:8462848-Mutation,
pubmed-meshheading:8462848-Phenotype,
pubmed-meshheading:8462848-RNA, Messenger,
pubmed-meshheading:8462848-Sex Determination Analysis,
pubmed-meshheading:8462848-X Chromosome
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pubmed:year |
1993
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pubmed:articleTitle |
Feedback control of sex determination by dosage compensation revealed through Caenorhabditis elegans sdc-3 mutations.
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pubmed:affiliation |
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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