Linked Life Data

8461608

Source:http://linkedlifedata.com/resource/pubmed/id/8461608

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-5-3
pubmed:abstractText
This study was undertaken to pharmacokinetically evaluate the efficacy of direct hemoperfusion under hepatic venous isolation (HVI-DHP) to cisplatin (CDDP) removal during hepatic arterial infusion. CDDP (2-4 mg/kg) was administered continuously to mongrel dogs through the hepatic artery for 10 min. Plasma levels and tissue concentrations were then compared between animals receiving CDDP alone (group 1, n = 4) and those treated with additional HVI-DHP for 20 min (group 2, n = 6). The peak CDDP levels in the right external jugular vein (systemic level) were 6.10 +/- 1.31 (mean +/- SD) and 1.41 +/- 0.12 micrograms/ml in groups 1 and 2 at a dosage of 2 mg/kg, respectively (P < 0.01). The estimated drug removal rates in group 2 animals at dosages of 2 and 4 mg/kg were 45.7 (mean, n = 5) and 46.9% (n = 1), respectively. The tissue concentrations of CDDP of the liver 30 min after the initiation of infusions were similar in both groups. The values of the liver, the heart, and the kidney were 1.90 +/- 0.55, 0.50 +/- 0.16, and 3.90 +/- 2.50 micrograms/g of wet tissue weight, respectively, in group 1. In contrast, tissue levels of the heart and the kidney in group 2 animals were significantly reduced, with the values at a dosage of 2 mg/kg being 0.21 +/- 0.03 micrograms/g (P < 0.01) and 0.86 +/- 0.53 micrograms/g (P < 0.05), respectively. This study demonstrated that the extrahepatic distribution of CDDP during hepatic arterial infusion can be reduced significantly by the concomitant use of HVI-DHP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0941-1291
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
58-62
pubmed:dateRevised
2006-8-3
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Extracorporeal cisplatin removal using direct hemoperfusion under hepatic venous isolation for hepatic arterial chemotherapy: an experimental study on pharmacokinetics.
pubmed:affiliation
First Department of Surgery, Kobe University School of Medicine, Japan.
pubmed:publicationType
Journal Article