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rdf:type |
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lifeskim:mentions |
umls-concept:C0001374,
umls-concept:C0002607,
umls-concept:C0006159,
umls-concept:C0026336,
umls-concept:C0026809,
umls-concept:C0026882,
umls-concept:C0031437,
umls-concept:C0039593,
umls-concept:C0080194,
umls-concept:C0205474,
umls-concept:C0241764,
umls-concept:C0441748,
umls-concept:C0599739,
umls-concept:C0681814,
umls-concept:C1516110
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pubmed:issue |
2
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pubmed:dateCreated |
1993-4-23
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pubmed:abstractText |
Breeding experiments were conducted to combine the X-linked sparse-fur (spf) mutation with ornithine transcarbamylase deficiency and the autosomal recessive deficiency of short-chain acyl CoA dehydrogenase (SCAD) in BALB/cByJ mice. We obtained spf/Y (scad/scad), spf/+ (scad/scad) and spf/spf (scad/scad) double mutants amongst the F2 progeny, which were tested and separated on the basis of urinary orotate and the GC/MS analysis of urinary butyrylglycine, methylsuccinate and ethylmalonate. The testing of the biochemical type was feasible both on the basis of a 24-h urine collection form adult mice kept in metabolic cages and on the basis of urine spots collected on filter paper from younger progeny. It is postulated that the spf/Y (scad/scad) double-mutant may serve as a useful animal model to study the ammonia: fatty acyl CoA synergism.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acyl Coenzyme A,
http://linkedlifedata.com/resource/pubmed/chemical/Acyl-CoA Dehydrogenases,
http://linkedlifedata.com/resource/pubmed/chemical/Ammonia,
http://linkedlifedata.com/resource/pubmed/chemical/Butyryl-CoA Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Malonates,
http://linkedlifedata.com/resource/pubmed/chemical/Ornithine Carbamoyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Orotic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Succinates,
http://linkedlifedata.com/resource/pubmed/chemical/ethylmalonic acid,
http://linkedlifedata.com/resource/pubmed/chemical/methylsuccinic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
191
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
744-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8461026-Acyl Coenzyme A,
pubmed-meshheading:8461026-Acyl-CoA Dehydrogenases,
pubmed-meshheading:8461026-Ammonia,
pubmed-meshheading:8461026-Animals,
pubmed-meshheading:8461026-Butyryl-CoA Dehydrogenase,
pubmed-meshheading:8461026-Crosses, Genetic,
pubmed-meshheading:8461026-Female,
pubmed-meshheading:8461026-Genes, Recessive,
pubmed-meshheading:8461026-Genetic Linkage,
pubmed-meshheading:8461026-Glycine,
pubmed-meshheading:8461026-Hair,
pubmed-meshheading:8461026-Male,
pubmed-meshheading:8461026-Malonates,
pubmed-meshheading:8461026-Mice,
pubmed-meshheading:8461026-Mice, Inbred BALB C,
pubmed-meshheading:8461026-Mice, Mutant Strains,
pubmed-meshheading:8461026-Mutation,
pubmed-meshheading:8461026-Ornithine Carbamoyltransferase,
pubmed-meshheading:8461026-Ornithine Carbamoyltransferase Deficiency Disease,
pubmed-meshheading:8461026-Orotic Acid,
pubmed-meshheading:8461026-Phenotype,
pubmed-meshheading:8461026-Succinates,
pubmed-meshheading:8461026-X Chromosome
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pubmed:year |
1993
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pubmed:articleTitle |
Breeding experiments to combine the X-linked sparse-fur (spf) mutation with the autosomal recessive BALB/cByJ strain: testing the biochemical phenotype of double-mutant mice as a model for ammonia: fatty acyl CoA synergism.
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pubmed:affiliation |
Service of Medical Genetics, Hôpital Sainte-Justine, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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