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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1993-4-28
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pubmed:abstractText |
The role of T cells expressing specific V beta elements was examined in the regulation of allergen-specific immunoglobulin (Ig)E production and airways responsiveness (AR). In BALB/c mice, inhalation of the allergen ovalbumin (OVA) induced an IgE anti-OVA response, immediate cutaneous reactivity, and increased AR. These results were associated with an expansion of V beta 8.1/8.2 T cells in local draining lymph nodes of the airways and the lung. Transfer of V beta 8.1/8.2 T cells from sensitized mice stimulated an IgE anti-OVA response, immediate cutaneous hypersensitivity, and increased AR in naive syngeneic recipients. In contrast, OVA-reactive V beta 2 T cells inhibited these effects. These data demonstrate for the first time that T cells with different V beta specificities play a critical role in the in vivo regulation of allergen-specific IgE production and AR.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-1385874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-1541669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-1607548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-1695667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-1834163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-1891008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-2419300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-2419430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-2459206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-2522501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-2786030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-2817596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-3107127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8459211-6228599
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1175-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8459211-Allergens,
pubmed-meshheading:8459211-Animals,
pubmed-meshheading:8459211-Bronchial Hyperreactivity,
pubmed-meshheading:8459211-Immunoglobulin E,
pubmed-meshheading:8459211-Mice,
pubmed-meshheading:8459211-Mice, Inbred BALB C,
pubmed-meshheading:8459211-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8459211-T-Lymphocytes
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pubmed:year |
1993
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pubmed:articleTitle |
T cells expressing specific V beta elements regulate immunoglobulin E production and airways responsiveness in vivo.
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pubmed:affiliation |
Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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