Linked Life Data

8458886

Source:http://linkedlifedata.com/resource/pubmed/id/8458886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-4-29
pubmed:abstractText
A simple, rapid, stability-indicating first-derivative spectrophotometric assay procedure for the determination of the degradation products of acetazolamide is described. The dissolution and kinetics of drug degradation in aqueous buffered solutions were studied using the proposed method. Acetazolamide solution exhibited optimum stability at pH 4. The influences of temperature and sonic energy on the degradation of acetazolamide in 0.01 M NaOH solution were also studied. The results showed first-order reaction kinetics, with a degradation rate constant and degradation half-life of 3.51 x 10(-3) day-1 and 8.23 days, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0269-4727
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-101
pubmed:dateRevised
2008-5-28
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
A stability-indicating first-derivative spectrophotometric assay of acetazolamide and its use in dissolution and kinetic studies.
pubmed:affiliation
Department of Pharmaceutical and Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
pubmed:publicationType
Journal Article