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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-4-29
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pubmed:abstractText |
The effects of sabeluzole, a drug that protects rat hippocampal neurones from glutamate- and N-methyl-D-aspartate (NMDA)-induced toxicity, were investigated in rat cerebellar granule cells in vitro with the whole-cell voltage clamp technique. Acute exposure of 0.1 microM sabeluzole for 20 min prior to experiments did not significantly affect glutamate receptor-mediated inward currents. Conversely, exposure of cultured granule cells to sabeluzole for 7 days reduced the NMDA-induced inward current and did not affect the non-NMDA responses evoked by kainic acid. The results suggest that chronic treatment with sabeluzole selectively reduces the functional NMDA response.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
232
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-4
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:8458392-Animals,
pubmed-meshheading:8458392-Cells, Cultured,
pubmed-meshheading:8458392-Cerebellum,
pubmed-meshheading:8458392-Membrane Potentials,
pubmed-meshheading:8458392-N-Methylaspartate,
pubmed-meshheading:8458392-Piperidines,
pubmed-meshheading:8458392-Rats,
pubmed-meshheading:8458392-Rats, Wistar,
pubmed-meshheading:8458392-Receptors, Glutamate,
pubmed-meshheading:8458392-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:8458392-Thiazoles
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pubmed:year |
1993
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pubmed:articleTitle |
Chronic sabeluzole treatment of cultured rat cerebellar granule cells reduces N-methyl-D-aspartate-induced inward current.
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pubmed:affiliation |
Research Institute of Toxicology, Utrecht University, Netherlands.
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pubmed:publicationType |
Journal Article
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