Linked Life Data

8458004

Source:http://linkedlifedata.com/resource/pubmed/id/8458004

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1993-4-28
pubmed:abstractText
The structure of an antigenic glycolipid isolated recently from cell walls of various strains of Mycobacterium tuberculosis and believed to be a sulfolipid consisting chiefly of 2,3-di-O-(hexadecanoyl/octadecanoyl)-alpha,alpha-trehalose 2'-sulfate (designated as SL-IV), was reinvestigated by mass spectrometry and nuclear magnetic resonance spectroscopy. The material proved to be a complex mixture of closely related components which are indeed 2,3-di-O-acyltrehaloses. However, no sulfate group was found in the antigen, and revision of its designation as a sulfolipid is therefore required. The lipid substituents comprise an estimated 20% of C14-C19 fatty acids, including tetradecanoic (myristic), 9-tetradecenoic (myristoleic), 9-hexadecenoic (palmitoleic), 9-octadecenoic (oleic), 10-methylhexadecanoic (tuberculopalmitic), and 10-methyloctadecanoic (tuberculostearic) acids in addition to hexadecanoic (palmitic) and octadecanoic (stearic) acids, and approximately 80% of higher, methyl-branched acids. Among the latter are, principally, 2,4-dimethyldocosanoic and 3-hydroxy-2,4,6- trimethyltetracosanoic acids, and a smaller proportion of 2,4,6-trimethyltetracos-2-enoic acid. Numerous further acids, related to those mentioned by methylene homology, are also present in small proportions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0008-6215
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
240
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The structure of an antigenic glycolipid (SL-IV) from Mycobacterium tuberculosis.
pubmed:affiliation
Ottawa-Carleton Chemistry Institute, Department of Chemistry, University of Ottawa, Ontario, Canada.
pubmed:publicationType
Journal Article