Linked Life Data

8457876

Source:http://linkedlifedata.com/resource/pubmed/id/8457876

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1993-4-27
pubmed:abstractText
During embryogenesis, the fiber tracts grow in a highly stereotyped pattern. A very small number of predetermined paths, preceding the growth of fasciculi, are present in the young neural tube (10-12, 15). What is the origin of these substrate pathways defined by Katz et al. (16) as "... a set of similar guidance cues which are aligned in a continuous discrete pathway..."? Could the first neurons play a role in the guidance of early nerve fibers? Observations in the brain stem revealed the presence of two longitudinal columns of early-generated neurons. These longitudinal columns were associated with well-differentiated marginal zones, characterized by cell-free spaces and representing the prospective site of the medial longitudinal (mlf) and lateral longitudinal (llt) tracts. Nerve fibers were also traced in the brain stem of young embryos. Axons were seen to travel in the early mlf and llt, in close proximity to the regions of early-generated neuronal columns. The data suggest that the precocious neurons that are organized in a definite pattern could somehow be involved in the guidance of some longitudinal axonal tracts, either by directly promoting the formation of an adequate terrain in the marginal layer, or by inducing other cells to do so.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The disposition of early-generated neurons in the rat embryo predicts the pattern of major axonal tracts.
pubmed:affiliation
Centre de Recherche en Neurobiologie, Hôpital de l'Enfant-Jésus, Québec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't