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rdf:type |
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lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0034805,
umls-concept:C0039194,
umls-concept:C0085732,
umls-concept:C0870432,
umls-concept:C1515021,
umls-concept:C1555465,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C1705417,
umls-concept:C1999230,
umls-concept:C2709248
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pubmed:issue |
3
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pubmed:dateCreated |
1993-4-16
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pubmed:abstractText |
A substantial body of evidence indicates that the primary sensitization of naive T cells to inhaled antigens occurs in the regional lymph nodes, whereas secondary responses may be generated directly within lung tissue. Ia+ pulmonary dendritic cells are widely distributed within the rat lung where they can participate in the induction of the immune response to inhaled antigens. Recently, two subsets of Ia+ pulmonary dendritic cells have been distinguished based on their expression of Fc receptors (FcR), but little is known concerning their abilities to support the responses of naive or sensitized T cells. In order to address this question, pulmonary FcR+/- dendritic cells have been purified from enzymatic digests of Lewis rat lungs, based on their differential binding to heat-aggregated immunoglobulin. The FcR+/- dendritic cell subsets differed with respect to their light microscopic appearance and in their expression of non-specific esterase. Only the FcR+ subset was able to phagocytize latex beads and showed intracellular phagolysosomes by electron microscopy. Both of the FcR+/- subsets rapidly formed clusters with naive (OX-22+) and sensitized (OX-22-) T cells. However, the clusters yielded by the FcR+ subset were substantially smaller, possibly reflecting their diminished surface membrane expression of the intercellular adhesion molecule-1. The FcR+/- subsets were capable of presenting soluble and particulate antigens to OX-22- T cells. FcR+ cells were less effective than FcR- cells in promoting the proliferative response of OX-22+ T cells to concanavalin A and in the primary mixed leukocyte reaction. We conclude that the FcR+/- pulmonary dendritic cells differ in their abilities to support the responses of naive and sensitized T lymphocytes. This observation may have significance for how primary and secondary pulmonary cell-mediated immune responses are generated.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-1689587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-1740664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-1900424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-1910679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-1910813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-1931075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-2139099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-2162904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-2191684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-2554698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-2936678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-2982730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-29936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-3004272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-315315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-3162253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-3264475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-3497747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-3499375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-3511172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-351618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-374095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-3871837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-4573839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-6162776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-6165237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-6206192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-6224884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8456942-6226588
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
142
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
811-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8456942-Animals,
pubmed-meshheading:8456942-Antigen-Presenting Cells,
pubmed-meshheading:8456942-Cell Aggregation,
pubmed-meshheading:8456942-Concanavalin A,
pubmed-meshheading:8456942-Dendritic Cells,
pubmed-meshheading:8456942-Female,
pubmed-meshheading:8456942-Histocompatibility Antigens Class II,
pubmed-meshheading:8456942-Immunization,
pubmed-meshheading:8456942-Lung,
pubmed-meshheading:8456942-Lymphocyte Activation,
pubmed-meshheading:8456942-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:8456942-Rats,
pubmed-meshheading:8456942-Rats, Inbred Lew,
pubmed-meshheading:8456942-Receptors, Fc,
pubmed-meshheading:8456942-T-Lymphocyte Subsets,
pubmed-meshheading:8456942-T-Lymphocytes
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pubmed:year |
1993
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pubmed:articleTitle |
FcR+/- subsets of Ia+ pulmonary dendritic cells in the rat display differences in their abilities to provide accessory co-stimulation for naive (OX-22+) and sensitized (OX-22-) T cells.
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pubmed:affiliation |
Department of Pathology, Massachusetts General Hospital, Boston 02114.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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