Linked Life Data

8456210

Source:http://linkedlifedata.com/resource/pubmed/id/8456210

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1993-4-21
pubmed:abstractText
A good measure of field vaccine efficacy should evaluate the direct protective effect of vaccination on the person who receives the vaccine. The conventional estimator for vaccine efficacy depends on population level factors that are either unrelated or indirectly related to the direct biological action of the vaccine on persons, including population structure, duration of the study, the fraction vaccinated, and herd immunity, that is, indirect effects. Indirect effects can cause the conventional vaccine efficacy estimator to be inaccurate. We review alternative vaccine efficacy estimators that control for indirect effects at the population level. Thus, they are more accurate than the conventional estimator. We use epidemic simulations to explore the robustness of the conventional and proposed estimators under different field conditions. In addition, we apply the different vaccine efficacy estimators to data from a measles epidemic in Muyinga, Burundi.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0277-6715
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
249-63
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Measuring vaccine efficacy from epidemics of acute infectious agents.
pubmed:affiliation
Division of Biostatistics, School of Public Health, Emory University, Atlanta, GA 30322.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.