Linked Life Data

8456110

Source:http://linkedlifedata.com/resource/pubmed/id/8456110

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-4-22
pubmed:abstractText
Prolactin release was examined from pituitary explants of ovariectomized, Fischer 344 rats at various times of estradiol treatment. The explants were acutely exposed to concentrations of dopamine from 0 to 10(-4) M and the concentration of prolactin in the resulting incubation medium was determined by radioimmunoassay. At 1 and 2 weeks of estradiol treatment, prolactin release from explants of Fischer 344 rats was not inhibited by 10(-6) or 10(-5) M dopamine when compared with release from explants exposed to no dopamine, whereas dopamine at doses of 10(-7) and 10(-8) M significantly stimulated prolactin release. By 3 or 4 weeks of estradiol treatment, the stimulatory effects of the low doses of dopamine were not evident and higher doses significantly inhibited prolactin release. These data indicate that dopamine can inhibit, stimulate, or produce no change in prolactin secretion and that these effects depend upon the concentration of dopamine used and the duration of estradiol treatment to which the animals are subjected.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
202
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
451-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Does dopamine inhibit or stimulate prolactin release in vitro? The effects of dopamine concentration and duration of in vivo estradiol treatment.
pubmed:affiliation
Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.