Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1993-4-20
|
| pubmed:abstractText |
Target antigens defined by autoantibodies in IDDM include insulin, a putative glycolipid that reacts with islet cell antibodies, and a 64,000-M(r) protein recently identified as glutamic acid decarboxylase. In addition, some IDDM sera that contain antibodies to glutamic acid decarboxylase also coprecipitate a 38,000-M(r) protein from islets. This study used a high titer anti-38,000-M(r) serum to screen bacteriophage lambda cDNA expression libraries and identified human islet and placental clones encoding jun-B, the nuclear transcription protein, of predicted 38,000 M(r). Peripheral blood T-cells exhibited significant proliferation in response to a recombinant fragment of jun-B (amino acids 1-180) in 12 of 17 (71%) recent-onset IDDM subjects, 8 of 16 (50%) ICA-positive first-degree relatives of IDDM subjects who were at risk, 3 of 12 (25%) other autoimmune disease subjects, and 0 of 10 healthy control subjects. Proliferation to tetanus toxoid did not differ significantly between the groups. Responses to jun-B were not related to age, sex, or human leukocyte antigen status. Thus, autoreactive T-cells identify a novel antigen, p38 jun-B, in IDDM and appear to indicate subjects at risk for the development of clinical disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-jun,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/islet cell antibody
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0012-1797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
626-30
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8454114-Adolescent,
pubmed-meshheading:8454114-Autoantibodies,
pubmed-meshheading:8454114-Autoantigens,
pubmed-meshheading:8454114-Autoimmune Diseases,
pubmed-meshheading:8454114-Child,
pubmed-meshheading:8454114-Cloning, Molecular,
pubmed-meshheading:8454114-Diabetes Mellitus, Type 1,
pubmed-meshheading:8454114-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:8454114-Female,
pubmed-meshheading:8454114-Glutathione Transferase,
pubmed-meshheading:8454114-Graves Disease,
pubmed-meshheading:8454114-Humans,
pubmed-meshheading:8454114-Islets of Langerhans,
pubmed-meshheading:8454114-Lymphocyte Activation,
pubmed-meshheading:8454114-Male,
pubmed-meshheading:8454114-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:8454114-Recombinant Proteins,
pubmed-meshheading:8454114-T-Lymphocytes
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Transcription factor jun-B is target of autoreactive T-cells in IDDM.
|
| pubmed:affiliation |
Burnet Clinical Research Unit, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|