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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-4-13
|
| pubmed:abstractText |
Recently, thromboxane synthetase inhibitor has been used for the treatment of preeclampsia. In this study, we investigated the effects of thromboxane synthetase inhibitor (OKY-046) on placental blood flow (measured with clearance of hydrogen gas generated by electrolysis) in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). The systolic blood pressure of OKY-046-treated SHR (1, 4 and 8 mg/kg) decreased significantly (p < 0.05); however, the systolic blood pressure of WKY did not decrease. The placental blood flow of both OKY-046-treated WKY and SHR did not decrease. We found that OKY-046 has no reducing effect on placental blood flow in rats, and systolic blood pressure of SHR decreases. These data suggest that thromboxane synthetase inhibitor might have a beneficial effect on preeclampsia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0378-7346
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
23-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8449429-Animals,
pubmed-meshheading:8449429-Blood Pressure,
pubmed-meshheading:8449429-Body Weight,
pubmed-meshheading:8449429-Disease Models, Animal,
pubmed-meshheading:8449429-Dose-Response Relationship, Drug,
pubmed-meshheading:8449429-Female,
pubmed-meshheading:8449429-Fetus,
pubmed-meshheading:8449429-Hypertension,
pubmed-meshheading:8449429-Methacrylates,
pubmed-meshheading:8449429-Organ Size,
pubmed-meshheading:8449429-Placenta,
pubmed-meshheading:8449429-Pregnancy,
pubmed-meshheading:8449429-Pregnancy Complications, Cardiovascular,
pubmed-meshheading:8449429-Rats,
pubmed-meshheading:8449429-Rats, Inbred SHR,
pubmed-meshheading:8449429-Rats, Inbred WKY,
pubmed-meshheading:8449429-Regional Blood Flow,
pubmed-meshheading:8449429-Systole,
pubmed-meshheading:8449429-Thromboxane-A Synthase
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Effects of thromboxane synthetase inhibitor (OKY-046) on placental blood flow, placental weight and fetal weight in normotensive and spontaneously hypertensive rats.
|
| pubmed:affiliation |
Department of Obstetrics and Gynecology, Tohoku University, School of Medicine, Sendai, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|