| pubmed-article:8449027 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8449027 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:8449027 | lifeskim:mentions | umls-concept:C0025219 | lld:lifeskim |
| pubmed-article:8449027 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:8449027 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8449027 | pubmed:dateCreated | 1993-4-15 | lld:pubmed |
| pubmed-article:8449027 | pubmed:abstractText | New Zealand white rabbits have a circadian rhythm of intraocular pressure; pressure is higher during the dark than during the light. We explored the possibility that the dark phase increase of serum and/or ocular melatonin plays a role in regulating the rhythm of intraocular pressure. Exogenous melatonin was delivered by four routes: topical application (0.1 and 10 micrograms), intravenous injection (1 microgram), intravitreal injection (9 micrograms) and intra-arterial infusion (50 ng and 1 microgram). Melatonin delivered by these routes did not increase intraocular pressure. We also measured the concentration of melatonin in the aqueous after unilateral intra-arterial infusion to confirm that melatonin delivered by this route reached the eye. The concentration was 419 +/- 99 and 109 +/- 17 pg/ml (n = 8, p < 0.025) in the ipsilateral and contralateral eyes, respectively. The concentration of melatonin in the aqueous after intra-arterial infusion of saline was less than the sensitivity of the assay (< 16 pg/ml, n = 6). The results of these experiments indicate that melatonin does not increase IOP significantly under the experimental conditions employed in this study. | lld:pubmed |
| pubmed-article:8449027 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8449027 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8449027 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8449027 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8449027 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8449027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8449027 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8449027 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8449027 | pubmed:issn | 0271-3683 | lld:pubmed |
| pubmed-article:8449027 | pubmed:author | pubmed-author:KiuchiYY | lld:pubmed |
| pubmed-article:8449027 | pubmed:author | pubmed-author:GregoryD SDS | lld:pubmed |
| pubmed-article:8449027 | pubmed:author | pubmed-author:MockovakM EME | lld:pubmed |
| pubmed-article:8449027 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8449027 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:8449027 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8449027 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8449027 | pubmed:pagination | 181-90 | lld:pubmed |
| pubmed-article:8449027 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:meshHeading | pubmed-meshheading:8449027-... | lld:pubmed |
| pubmed-article:8449027 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8449027 | pubmed:articleTitle | Melatonin does not increase IOP significantly in rabbits. | lld:pubmed |
| pubmed-article:8449027 | pubmed:affiliation | Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT. | lld:pubmed |
| pubmed-article:8449027 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8449027 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8449027 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
