Linked Life Data

8448601

Source:http://linkedlifedata.com/resource/pubmed/id/8448601

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-4-9
pubmed:abstractText
1. The effect of topical betamethasone upon skin blood flow was investigated in the rat. Two types of vasodilator stimuli were used; local heating to the surface of the skin and intradermal application of inflammatory agents. Blood flow was measured by laser doppler velocimetry. 2. Topical betamethasone-17-valerate (1 g with an 18 h pretreatment) significantly inhibited the heat-induced vasodilatation in the rat skin, as also did systemically administered betamethasone (1 mg kg-1, 3 h pretreatment). 3. Angiotensin converting enzyme (ACE) inhibitors (captopril, 5 mg kg-1 and enalapril, 1 mg kg-1, 30 min pretreatments) were the only drugs out of several different types of systemically administered inhibitors and antagonists that were tested which also inhibited the heat-induced vasodilatation. Aprotinin (100,000 KIU kg-1, 5 min pretreatment) a serine protease inhibitor, significantly potentiated the heat-induced response. 4. Bradykinin (50 nmol per site), des-Arg9-bradykinin (5 nmol per site), substance P (0.1 nmol per site) and capsaicin (1 mumol per site) induced an increase in skin blood flow. 5. Topical betamethasone treatment resulted in a significant inhibition of the vasodilator response to des-Arg9-bradykinin, whereas captopril treatment inhibited the responses to substance P, capsaicin, bradykinin and des-Arg9-bradykinin. 6. Intradermal application of captopril (10-100 micrograms) also caused a dose-dependent inhibition of the heat-induced vasodilatation. 7. These results suggest that topical betamethasone may be acting in a manner similar to that of the ACE inhibitors to produce an inhibition of the flow responses in the skin and that this effect may be brought about by interfering with the action of vasodilator peptide(s) or protein(s).
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8448601-13742412, http://linkedlifedata.com/resource/pubmed/commentcorrection/8448601-13742413, http://linkedlifedata.com/resource/pubmed/commentcorrection/8448601-1504745, http://linkedlifedata.com/resource/pubmed/commentcorrection/8448601-2874773, http://linkedlifedata.com/resource/pubmed/commentcorrection/8448601-2943820, http://linkedlifedata.com/resource/pubmed/commentcorrection/8448601-3390663, http://linkedlifedata.com/resource/pubmed/commentcorrection/8448601-3676593, http://linkedlifedata.com/resource/pubmed/commentcorrection/8448601-593374, http://linkedlifedata.com/resource/pubmed/commentcorrection/8448601-6203590, http://linkedlifedata.com/resource/pubmed/commentcorrection/8448601-6660915, http://linkedlifedata.com/resource/pubmed/commentcorrection/8448601-7126601
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
544-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Investigations into the mechanism of vasoconstrictor action of the topical steroid betamethasone-17-valerate in the rat.
pubmed:affiliation
Department of Biochemical Pharmacology, William Harvey Research Institute, St. Bartholomew's Medical College, London.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't