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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-4-15
|
| pubmed:abstractText |
The dihydroisocoumarins (+-)-6-methoxy-8-hydroxy-3-methyl-3,4- dihydroisocoumarin (1), (+-)-6,8-dihydroxy-3-methyl-3,4-dihydroisocoumarin (2), and (+-)-6,8-dimethoxy-3-methyl-3,4-dihydroisocoumarin (3) were synthesized with high yields via metalation of o-methylbenzamides. The toxicity of these compounds and that of (-)-1 extracted from carrot cells were tested, in vitro, on Chinese hamster cells. The toxicity was determined according to the presence or absence of a hydroxyl group in the peri position of the lactonic carbonyl group and according to the stereochemistry of the dihydroisocoumarin.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0893-228X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
46-9
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8448349-Animals,
pubmed-meshheading:8448349-Cell Line,
pubmed-meshheading:8448349-Cells, Cultured,
pubmed-meshheading:8448349-Coumarins,
pubmed-meshheading:8448349-Cricetinae,
pubmed-meshheading:8448349-Cricetulus,
pubmed-meshheading:8448349-Indicators and Reagents,
pubmed-meshheading:8448349-Isocoumarins,
pubmed-meshheading:8448349-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8448349-Plants,
pubmed-meshheading:8448349-Spectrophotometry, Infrared,
pubmed-meshheading:8448349-Stereoisomerism
|
| pubmed:articleTitle |
Synthesis and toxicity to mammalian cells of the carrot dihydroisocoumarins.
|
| pubmed:affiliation |
Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Italy.
|
| pubmed:publicationType |
Journal Article
|