Linked Life Data

844797

Source:http://linkedlifedata.com/resource/pubmed/id/844797

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1977-5-25
pubmed:abstractText
The influence of the flavonolignane derivatives silybin, silybinhemisuccinate and silybindihemisuccinate on the RNA synthesis in isolated nuclei from rat livers was studied. A stimulatory effect of silybin on the incorporation of [3H]UTP into nuclear RNA was found and the dose dependence could be demonstrated. The results support former findings that silybin stimulates RNA synthesis in rat livers in vivo and in hepatocytes. Experiments with purified nucleoli indicated that mainly the rate of rRNA synthesis is increased. The mechanism of this stimulation was elucidated by experiments with isolated RNA polymerases. It could be demonstrated that polymerase B is not affected by the flavonolignane, but the activity of polymerase A is increased, due to higher V at constant Km values. Thus silybin is shown to be an enzyme-stimulating effector.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0018-4888
pubmed:author
pubmed:issnType
Print
pubmed:volume
358
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Mechanism of the stimulation of RNA synthesis in rat liver nuclei by silybin.
pubmed:publicationType
Journal Article, In Vitro