Linked Life Data

8447206

Source:http://linkedlifedata.com/resource/pubmed/id/8447206

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-4-5
pubmed:abstractText
In order to clarify the relative contribution of the liver to the short-term disposition of sufentanil, hepatic blood flow was measured during induction of anaesthesia with a 10 micrograms/kg i.v. bolus dose of sufentanil followed by a continuous infusion of 0.3 microgram/kg/min of sufentanil. The hepatic clearance of the drug was 0.57 l/min after induction and 0.55 l/min at sternotomy, its hepatic extraction 92% and 91%, respectively. As a consequence of the high hepatic extraction, the hepatic clearance of sufentanil was closely dependent on hepatic plasma flow. Comparing the hepatic clearance of sufentanil with data from the literature for total body clearance of sufentanil, there is a significant difference of more than 0.3 l/min. It is concluded that there is evidence for a relevant extrahepatic disposition of sufentanil.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0001-5172
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
154-8
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Hepatic disposition of sufentanil in patients undergoing coronary bypass surgery.
pubmed:affiliation
Department of Clinical Anaesthesiology, University of Göttingen, FRG.
pubmed:publicationType
Journal Article