Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1993-4-8
|
pubmed:abstractText |
The effects of 4 weeks of cyclosporin A (7 mg/kg per day) (CyA) on the survival of vascularized osteochondral grafts between rat strains [DA (donor) and Lewis (recipient)] and the presence and significance of host immune tolerance and graft antigen modulation after cessation of immunosuppression have been examined. Isografts (n = 12) survived without apparent abnormality for 8 weeks but showed signs of wasting after longer periods; unprotected allografts (n = 5) were rejected within 2 weeks. After 4 weeks of CyA, allografts remained healthy for at least 12 weeks but then deteriorated (n = 40). Antigen modulation was examined by graft removal at various intervals after cessation of CyA and reimplantation into a naive recipient (n = 14). All were rejected rapidly. Host tolerance was examined by graft removal at various periods after cessation of CyA and reimplantation of a fresh allograft (n = 15). Some of the second grafts survived at least 4 weeks without immunosuppression. The findings indicate development of incomplete host tolerance but no antigenic modulation of the graft.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0032-1052
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
91
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
597-605; discussion 606-7
|
pubmed:dateRevised |
2011-2-16
|
pubmed:meshHeading |
pubmed-meshheading:8446712-Animals,
pubmed-meshheading:8446712-Bone Transplantation,
pubmed-meshheading:8446712-Cartilage,
pubmed-meshheading:8446712-Cyclosporine,
pubmed-meshheading:8446712-Graft Rejection,
pubmed-meshheading:8446712-Graft Survival,
pubmed-meshheading:8446712-Immune Tolerance,
pubmed-meshheading:8446712-Immunosuppression,
pubmed-meshheading:8446712-Rats,
pubmed-meshheading:8446712-Rats, Inbred Lew,
pubmed-meshheading:8446712-Time Factors,
pubmed-meshheading:8446712-Transplantation, Homologous,
pubmed-meshheading:8446712-Transplantation, Isogeneic
|
pubmed:year |
1993
|
pubmed:articleTitle |
Vascularized osteochondral allografts in an immunosuppressed rat model: graft modulation and host immune tolerance.
|
pubmed:affiliation |
Microsurgery Research Centre, St. Vincent's Hospital, Melbourne, Australia.
|
pubmed:publicationType |
Journal Article
|