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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1993-4-7
|
| pubmed:abstractText |
Septohippocampal cholinergic system involvement in acquisition of an aversively motivated 14-unit T-maze was evaluated in 4-month-old male Fischer-344 rats. Each rat was assigned to one of two groups that received either a bilateral electrolytic lesion to the medial septal area (MSA) or a sham operation. One week after surgery, each rat began pretraining in one-way active avoidance (footshock = 0.8 mA) consisting of 10 trials per day on each of 3 consecutive days. Criterion for successful completion of pretraining was 8/10 avoidances on the third day. On the day following completion of pretraining, each rat received 10 trials in a shock-motivated 14-unit T-maze. The performance requirement was to move through each of five maze segments within 10 s to avoid footshock (0.8 mA). A second 10-trial session was provided 24 h later. Performance measures included errors, alternation errors, runtime, shock frequency, and duration. Following maze training, each rat was sacrificed, and formalin-fixed brains were frozen for histology, which included procedures for thionin Nissl and acetylcholinesterase (AChE) staining. MSA-lesioned rats were observed to be significantly impaired on all measures of maze performance compared to sham-operated controls. Densitometric analysis of hippocampal AChE staining revealed a 30% reduction in relative AChE staining of MSA-lesioned rats compared to sham-operated controls. Lesion size was observed to be highly positively correlated with maze errors. A negative correlation of mean error score with density of AChE staining was observed for MSA-lesioned rats, but not for sham-operated rats.(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
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| pubmed:issn |
0031-9384
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
53
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
221-8
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:8446684-Acetylcholinesterase,
pubmed-meshheading:8446684-Aging,
pubmed-meshheading:8446684-Animals,
pubmed-meshheading:8446684-Arousal,
pubmed-meshheading:8446684-Avoidance Learning,
pubmed-meshheading:8446684-Brain Mapping,
pubmed-meshheading:8446684-Cholinergic Fibers,
pubmed-meshheading:8446684-Discrimination Learning,
pubmed-meshheading:8446684-Hippocampus,
pubmed-meshheading:8446684-Male,
pubmed-meshheading:8446684-Mental Recall,
pubmed-meshheading:8446684-Nerve Degeneration,
pubmed-meshheading:8446684-Neural Pathways,
pubmed-meshheading:8446684-Orientation,
pubmed-meshheading:8446684-Problem Solving,
pubmed-meshheading:8446684-Rats,
pubmed-meshheading:8446684-Rats, Inbred F344,
pubmed-meshheading:8446684-Retention (Psychology),
pubmed-meshheading:8446684-Septal Nuclei
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Impaired acquisition in a 14-unit T-maze following medial septal lesions in rats is correlated with lesion size and hippocampal acetylcholinesterase staining.
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| pubmed:affiliation |
Molecular Physiology and Genetics Section, Nathan W. Shock Laboratories, Gerontology Research Center, Baltimore, MD.
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| pubmed:publicationType |
Journal Article
|