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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1993-4-8
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pubmed:abstractText |
To examine the in vivo function of IgD we generated mice deficient for IgD by gene targeting. The IgD-mice show a reduced B-cell compartment with 30-50% less B cells in the spleen and lymph nodes but show a normal pre-B-cell compartment. The surface-IgD- B cells express two to three times more surface IgM than B cells of control animals. Serum concentrations of the immunoglobulin isotypes of IgD- mice are almost normal, indicating that surface-IgD expression is not necessary for class switching of B cells. Immunization experiments showed that IgD- mice could respond well to thymus-dependent and -independent antigens. After immunization normal germinal centers developed in the IgD- mice. These data suggest that IgD is not necessary for the induction of immune responses but may be important in homeostasis of cells in the B-cell compartment.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-150972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-1838007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-2408798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-2414388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-2822260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-306413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-3128612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-313424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-3137579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-3143916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-3194019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-3261841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-3261870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-3582489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-379216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-3897439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-6170707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-6177773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-6203757,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-68987,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/8446604-94425
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1887-91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8446604-Agammaglobulinemia,
pubmed-meshheading:8446604-Animals,
pubmed-meshheading:8446604-Antigens, T-Independent,
pubmed-meshheading:8446604-B-Lymphocytes,
pubmed-meshheading:8446604-Histocompatibility Antigens Class II,
pubmed-meshheading:8446604-Immunity,
pubmed-meshheading:8446604-Immunoglobulin D,
pubmed-meshheading:8446604-Immunoglobulin Isotypes,
pubmed-meshheading:8446604-Lymphoid Tissue,
pubmed-meshheading:8446604-Mice,
pubmed-meshheading:8446604-T-Lymphocytes
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pubmed:year |
1993
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pubmed:articleTitle |
Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens.
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pubmed:affiliation |
Max-Planck Institute for Immunobiology, Freiburg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article
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